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Notre Dame researchers offer new insights on cancer cell signaling

Author: William G. Gilroy

Wnt proteins and cancer cell signaling

A pair of studies by a team of University of Notre Dame researchers led by Crislyn D’Souza-Schorey, professor of biological sciences, sheds light on a biological process that is activated across a vast range of malignancies.

Wnt proteins are a large family of proteins that activate signaling pathways (a set of biological reactions in a cell) to control several vital steps in embryonic development. In adults, Wnt-mediated functions are frequently altered in many types of cancers and, specifically, within cell subpopulations that possess stem cell-like properties.

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